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Total 80195 results found since Jan 2013.

Modeling Amyotrophic Lateral Sclerosis in hSOD1 Transgenic Swine.
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that occurs in two clinically indistinguishable forms: sporadic (SALS) and familial (FALS), the latter linked to several gene mutations, mostly inheritable in a dominant manner. Nearly 20% of FALS forms are linked to mutations in the Cu/Zn superoxide dismutase (SOD1) gene. Research on ALS relies on transgenic models and particularly on mice carrying a glycine-to-alanine conversion at the 93rd codon (G93A) of the hSOD1 gene. Although G93A transgenic mice have been widely employed in clinical trials and basic research, doubts have been...
Source: Neuro-Degenerative Diseases - October 23, 2013 Category: Neurology Authors: Chieppa MN, Perota A, Corona C, Grindatto A, Lagutina I, Vallino Costassa E, Lazzari G, Colleoni S, Duchi R, Lucchini F, Caramelli M, Bendotti C, Galli C, Casalone C Tags: Neurodegener Dis Source Type: research

A novel swine model of subarachnoid hemorrhage-induced cerebral vasospasm
Conclusions: The relative scarcity of swine models for SAH-induced vasospasm motivated us to develop and quantify a straightforward protocol for producing consistent mild-to-moderate vasospasm following SAH. As swine is commonly used in translational cardiovascular research, we believe that this study constitutes an important phase in the study of SAH and in developing pharmacological agents and medical devices for interventions.
Source: Neurology India - September 6, 2017 Category: Neurology Authors: Zion Zibly Lory Fein Mayur Sharma Yaron Assaf Anton Wohl Sagi Harnof Source Type: research

Intracranial electrophysiological recordings on a swine model of mesial temporal lobe epilepsy
This study measured intracranial electrophysiological activity in a swine model of KA-induced mesial temporal lobe epilepsy (mTLE). Using the clinical SEEG electrode, we distinguished abnormal EEG patterns in the swine brain. The high test–retest reliability of HFO rates in the post-KA period suggests the utility of this model for studying mechanisms of epileptogenesis. The use of swine may provide satisfactory translational value for clinical epilepsy research.
Source: Frontiers in Neurology - April 17, 2023 Category: Neurology Source Type: research

When Pigs Fly: Dynamic Susceptibility Contrast MRI for Cerebral White Matter Injury in a Hypobaric Swine Model (P5.202)
CONCLUSIONS: DSC is highly stable and reproducible on repetitive magnetic resonance imaging (MRI) and thus a valid technique for measuring hypobaria-induced swine brain injury. No breakdown of the blood brain barrier was detected. Lack of demonstrable change may be due to timing of the post-exposure MRI, possible neuroprotective effects of anesthesia during exposure, insufficient neurologic stress during flight due to sedation, potential variable bio-susceptibility of the swine brain to hypobaric injury. Further model development and studies are warranted.Disclosure: Dr. Peralta has nothing to disclose. Dr. Sladky has noth...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Peralta, P. D., Sladky, J., McGuire, S. Tags: Aging and Dementia: Disease Models and Mechanisms Source Type: research

Quantitative electroencephalography in a swine model of blast-induced brain injury.
CONCLUSIONS: This study demonstrated that qEEG is sensitive for cerebral injury. The changes of qEEG earlier after the blast indicate the potential of utilization of multiple parameters of qEEG for diagnosis of blast-induced brain injury. Early detection of blast induced brain injury will allow early screening and assessment of brain abnormalities in soldiers to enable timely therapeutic intervention. PMID: 27830938 [PubMed - as supplied by publisher]
Source: Brain Injury - November 12, 2016 Category: Neurology Tags: Brain Inj Source Type: research

Left Ventricular Function in the Initial Period After Severe Traumatic Brain Injury in Swine
ConclusionsTraumatic brain injury is associated with cardiac dysfunction and increased mortality, however there is still a limited understanding of the hemodynamic and echocardiographic response associated with TBI. In this study we demonstrate the hemodynamic and echocardiographic changes in the early stages of TBI in swine. The authors hope that these results may help better understanding on the management of patients with severe head injury.
Source: Neurocritical Care - March 21, 2022 Category: Neurology Source Type: research

Intracranial Pulsating Balloon-Based Cardiac-Gated ICP Modulation Impact on Brain Oxygenation: A Proof-of-Concept Study in a Swine Model
ConclusionsIntracranial cardiac-gated balloon pump activation can influence cerebral oxygenation and raise PbtO2 above threshold values. This study supports the concept of late-diastolic pressure rise, coupled with early-systolic pressure drop, as a potential effector of flow augmentation leading to improve brain tissue oxygenation. Further studies are warranted to assess the translational potential of using an intracranial cardiac-gated balloon pump device to improve brain tissue oxygenation.
Source: Neurocritical Care - November 18, 2022 Category: Neurology Source Type: research

Vascular Inflammation Imaging with 18F-FDG PET/CT for In-Stent Restenosis after Intracranial Stent Deployment in a Swine Model (S51.002)
Conclusions: This swine model is suitable for the testing of devices for the endovascular treatment of intracranial atherosclerosis. It can be a useful tool for the study of inflammation mechanisms of in-stent restenosis after intracranial stenting therapies.Disclosure: Dr. Shi has nothing to disclose. Dr. Liu has nothing to disclose. Dr. Wang has nothing to disclose. Dr. Liu has nothing to disclose. Dr. Shi has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Chen has nothing to disclose. Dr. Liu has nothing to disclose. Dr. Liu has nothing to disclose. Dr. Wang has nothing to disclose. Dr. Feng has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Shi, Z.-S., Liu, Z., Wang, J.-S., Liu, D.-H., Shi, X.-C., Zhang, X.-S., Chen, D.-J., Liu, Y., Liu, Y.-Q., Wang, Q.-Y., Feng, L. Tags: Cerebrovascular Disease and Interventional Neurology: Large Vessel Atherosclerotic Disease Source Type: research

Neuronal Plasmalemmal Disruptions are Exacerbated in Perivascular Domains Following Repetitive Traumatic Brain Injury in Swine (I5-1A)
CONCLUSIONS: These results suggest that micro-structural discontinuities at vasculature-brain tissue interfaces contribute to exacerbated plasmalemmal damage following TBI. Ongoing analyses are assessing the co-occurrence of plasmalemmal damage with the emergence of traumatic proteinopathies and evolving neurodegeneration. Study Supported by: Department of Veterans Affairs (RR&D Merit Award #B1097-I), National Institutes of Health (NINDS T32-NS043126), and Penn’s University Research Foundation.Disclosure: Dr. Duda holds stock and/or stock options in General Electric and Celgene, Inc. Dr. Harris has nothing to dis...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Duda, J., Harris, J., Kuo, E., Cullen, D. Tags: Pediatric Neurotrauma: From Coma to Concussions Data Blitz Presentations Source Type: research

Neuronal Plasmalemmal Disruptions are Exacerbated in Perivascular Domains Following Repetitive Traumatic Brain Injury in Swine (S27.006)
CONCLUSIONS: These results suggest that micro-structural discontinuities at vasculature-brain tissue interfaces contribute to exacerbated plasmalemmal damage following TBI. Ongoing analyses are assessing the co-occurrence of plasmalemmal damage with the emergence of traumatic proteinopathies and evolving neurodegeneration. Study Supported by: Department of Veterans Affairs (RR&D Merit Award #B1097-I), National Institutes of Health (NINDS T32-NS043126), and Penn’s University Research Foundation.Disclosure: Dr. Duda holds stock and/or stock options in General Electric and Celgene, Inc. Dr. Harris has nothing to dis...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Duda, J., Harris, J., Kuo, E., Cullen, D. Tags: Neuro Trauma, Critical Care, and Sports Neurology Source Type: research

A proposed mechanism for hypobaric-induced neuronal injury: a swine model (p4.068)
Conclusions:PDI and kurtosis demonstrate an increase in unrestricted water after repetitive hypobaric exposure, consistent with injury. The significant decrease in FA at 4 weeks suggests degradation of axonal integrity. This replicates similar MRI findings in humans. The study provides evidence that repetitive hypobaric exposure incites axonal damage, and that swine may be a feasible animal model with which to improve our understanding of injury mechanisms and potentially test interventions that could reduce hypobaric neuronal injury in the future.Study Supported by:Research is sponsored by USAF/SG, 711HPW, 59MDW, and JPC-...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Peralta, P. D., Sladky, J., Sherman, P., McGuire, S. Tags: General Neurology: Vascular Neurology Source Type: research

Hypothermia-induced neuroprotection is associated with reduced mitochondrial membrane permeability in a swine model of cardiac arrest
i & Chunsheng Li
Source: Journal of Cerebral Blood Flow - March 13, 2013 Category: Neurology Authors: Ping GongRong HuaYu ZhangHong ZhaoZiren TangXue MeiMingyue ZhangJuan CuiChunsheng Li Tags: cardiac arrest mitochondria mild hypothermia neuroprotection pig reperfusion Source Type: research

Propofol compared with isoflurane inhibits mitochondrial metabolism in immature swine cerebral cortex
p; Michael A Portman
Source: Journal of Cerebral Blood Flow - January 8, 2014 Category: Neurology Authors: Masaki KajimotoDouglas B AtkinsonDolena R LedeeErnst-Bernhard KayserPhil G MorganMargaret M SedenskyNancy G IsernChristine Des RosiersMichael A Portman Tags: anesthesia energy metabolism glucose mitochondria MR spectroscopy Source Type: research

Brain CD47 expression in a swine model of intracerebral hemorrhage.
In conclusion, CD47 expression was increased in the perihematomal white and grey matter after ICH. Deferoxamine and iron may modulate CD47 expression. PMID: 24931767 [PubMed - as supplied by publisher]
Source: Brain Research - June 12, 2014 Category: Neurology Authors: Zhou X, Xie Q, Xi G, Keep RF, Hua Y Tags: Brain Res Source Type: research

Rewarming from therapeutic hypothermia induces cortical neuron apoptosis in a swine model of neonatal hypoxic–ischemic encephalopathy
Rewarming from therapeutic hypothermia induces cortical neuron apoptosis in a swine model of neonatal hypoxic–ischemic encephalopathy Journal of Cerebral Blood Flow & Metabolism advance online publication, January 7 2015. doi:10.1038/jcbfm.2014.245 Authors: Bing Wang, Jillian S Armstrong, Jeong-Hoo Lee, Utpal Bhalala, Ewa Kulikowicz, Hui Zhang, Michael Reyes, Nicole Moy, Dawn Spicer, Junchao Zhu, Zeng-Jin Yang, Raymond C Koehler, Lee J Martin & Jennifer K Lee
Source: Journal of Cerebral Blood Flow - January 7, 2015 Category: Neurology Authors: Bing WangJillian S ArmstrongJeong-Hoo LeeUtpal BhalalaEwa KulikowiczHui ZhangMichael ReyesNicole MoyDawn SpicerJunchao ZhuZeng-Jin YangRaymond C KoehlerLee J MartinJennifer K Lee Tags: asphyxia heart arrest hypothermia neuronal cell death newborn rewarming Source Type: research